Home > Search Results: keywords:"Bakteriální biofilmy"
Search:
Search Tips :: Advanced Search
Search collections:
Sort by: Display results: Output format:
National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Coordinatively unsaturated complexes with potential nucleasic activity
 Willimetz, Robert ; Kotek, Jan (advisor) ; Schulz, Jiří (referee)
Biofilms are bacterial colonies attached to the surfaces through matrix of the biopolymer substances they produce. These biofilms can also form on medical implants, where they are responsible for difficult-to-treat chronic infections. One approach to prevent biofilm formation may be using of coordination compounds with nuclease activity. These compounds contain a hydrolytically active metal ion that is able to actively cleave extracellular DNA to prevent matrix and biofilm formation. The aim of this diploma thesis was to prepare a series of Cu(II) complexes of 1,4,7-triazacyclononane derivatives and to observe their potential nuclease activity. One of the complexes was a 1,4,7-triazacyclononane derivative with a thiazole anchor. Prepared complex can be incorporated through this anchor into polymers to a surface with potential ability to prevent biofilm formation.
Detailed record
Testing of anti-microbial and anti-adhesive properties of nanodiamond materials
 Jurková, Blanka ; Beranová, Jana (advisor) ; Lišková, Jana (referee)
Nanocrystalline diamond (NCD) films possess great mechanical properties (low friction coefficient, high hardness etc.), chemical properties (e.g. low corrosivity or chemical inertness) and good biocompatibility. This makes them perspective materials for protective coatings of medical implants and devices. As bacteria biofilms are often very resistant to antibacterial treatment, materials with anti-bacterial or at least anti-adhesive properties are needed. The interaction of NCD films with bacteria has not been properly examined yet. The aim of this thesis was to introduce and optimize the methods for routine bacterial biofilm cultivation and analysis, use them to investigate the ability of NCD films to inhibit the attachment and biofilm formation of Escherichia coli and correlate it with the NCD surface hydrophobicity. The materials used for the study were hydrogenated NCD (hydrophobic), oxidized NCD (hydrophilic) and uncoated glass. For bacterial biofilm growth, cultivation in six-well plates and continuous cultivation in CDC Bioreactor was used. Several methods were tested for quantitative biofilm detachment and analysis. The putative anti-bacterial properties of NCD material were not confirmed in this work. Higher bacterial attachment to NCD films in comparison to the uncoated glass was...
Detailed record

Interested in being notified about new results for this query?
Subscribe to the RSS feed.
Digital Repository :: Search :: Submit :: Personalize :: Help
Powered by Invenio v1.1.2
Maintained by admin.invenio@techlib.cz
This site is also available in the following languages:
Česky  English